RCOPT
เผยแพร่ผลงานวิจัยของจักษุแพทย์ไทย ในจดหมายข่าว Academy Express
Updated 2021-10-05 12:03:00
เผยแพร่ผลงานวิจัยของจักษุแพทย์ไทย ในจดหมายข่าว Academy Express
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อ่านผลงานวิจัยในจดหมายข่าว Academy
Express-Asia Pacific Edition ฉบับย้อนหลัง
January
2021 February
2021 March
2021 April
2021 May
2021 June
2021
June 2021
Academy Express ฉบับวันที่ 26
June 2021
Intravitreal
mesenchymal stem cells show promise for retinitis pigmentosa
Researchers assessed the use of intravitreal autologous
mesenchymal stem cell transplantation in 14 patients with advanced retinitis
pigmentosa. During a 12-month period, patients exhibited stable conditions and
slow disease progression, with some reporting improved quality of life. Adverse
events were mild and included slight IOL displacement and flat choroidal
detachment. Additional studies are warranted. Stem Cell Research &
Therapy, January 2021
https://pubmed.ncbi.nlm.nih.gov/33422139/
Academy Express ฉบับวันที่ 19
June 2021
Successful management
of complete ankyloblepharon with SOMET
In this case, the authors describe a patient with complete ankyloblepharon who
was successfully managed with simple oral mucosal epithelial transplantation
(SOMET). Six weeks after treatment, the patient had complete epithelization of
corneal-like epithelium. Although there was evidence of conjunctival invasion,
the ocular surface was stable for 1 year and both fornices remained deep. Cornea,
January 2021
https://pubmed.ncbi.nlm.nih.gov/33416218/
Academy Express ฉบับวันที่ 12
June 2021
Surgical treatment is
key for globe salvage in case of contact lens-related Pythium keratitis
This study describes 6 cases of contact lens-related Pythium keratitis. Five
patients used soft contact lenses and one used rigid gas-permeable lenses; all patients
had a history of water contamination. All patients had tentacle-like lesions
radiating in a reticular pattern and were treated with therapeutic penetrating
keratoplasty after failing to response to medical treatment. One patient
underwent enucleation and 5 achieved globe salvage. Cornea, January 2021
https://pubmed.ncbi.nlm.nih.gov/33470674/
Academy Express ฉบับวันที่ 5
June 2021
Eye injuries with
IOFBs yield poor visual outcomes
This study describes the visual outcomes of 359 patients with eye injuries and
retained intraocular foreign bodies (IOFB). Most patients had poor final BCVA.
Predictive factors for poor visual outcomes included poor presenting BCVA,
retinal detachment and endophthalmitis. The authors concluded that these
factors could help with diagnostic decision making and treatment to help
improve final outcomes. Clinical Ophthalmology, January 2021
https://pubmed.ncbi.nlm.nih.gov/33456307/
May 2021
Academy Express ฉบับวันที่ 29
May 2021
Microvascular
attenuation in eyes with resolved AACG is comparable to POAG
Researchers compared peripapillary perfused capillary density (PCD) in eyes
with resolved acute angle-closure (AACG) and primary open angle glaucoma
(POAG). Imaging with OCT angiography showed that the degree of microvascular
attenuation in both groups was similar. The authors recommend ending use of
glaucoma medication after IOP normalization but note the need for additional
research to explain the relationship between PCD alterations and IOP-induced
damage. Asia Pacific Journal of Ophthalmology, March-April 2021
https://pubmed.ncbi.nlm.nih.gov/33481392/
Academy Express ฉบับวันที่ 22
May 2021
Vitreous block can
occur in patients with pseudophakia
In this paper, the authors describe a patient with pseudophakic angle closure
due to vitreous block after ureteroscopic lithotripsy under general anesthesia.
They note that this patient had vitreous prolapse due to a prior trauma with
inadequate vitrectomy. General anesthesia, they added, might contribute to
vitreous block in susceptible patients. International Medical Case Reports,
January 2021
https://pubmed.ncbi.nlm.nih.gov/33536795/
Academy Express ฉบับวันที่ 15
May 2021
Deep learning model
for anterior segment OCT may help detect plateau iris
This study tested a deep learning model for detecting plateau iris from
anterior segment OCT images. Using scans from 179 patients with primary
angle-closure disease (PACD), the model performed with 88% sensitivity and 98%
specificity. The authors conclude that it could potentially help better detect
this non-pupillary block mechanisms in patients with this PACD. Translational
Vision Science & Technology, January 2021
https://pubmed.ncbi.nlm.nih.gov/33505774/
Academy Express ฉบับวันที่ 8
May 2021
Sterilization of
single-use instruments can help mitigate
endophthalmitis after vitrectomy
This retrospective study assesses the rate of endophthalmitis after pars plana
vitrectomy (PPV) with recycled single-use devices. There was no statistical
difference in the rate of endophthalmitis among patients who underwent 23- or
25-gauge vitrectomy. In addition, the authors report that their standardized
protocol for instrument sterilization led to endophthalmitis rate that were
comparable to previous studies that disposed of vitrectomy tools after one use.
International Journal of Retina and Vitreous, January 2021
https://pubmed.ncbi.nlm.nih.gov/33407931/
Academy Express ฉบับวันที่ 1
May 2021
Pseudoexfoliation
syndrome has greater microvascular attenuation than true exfoliation syndrome
Researchers compared peripapillary perfused capillary density (PCD) in eyes
with true exfoliation (TEX) and pseudoexfoliation (PEX) syndrome. Imaging by
OCT angiography revealed that the PEX group had a greater loss of annular PCD
than both the TEX group and healthy eyes. These findings suggest more
microvascular attenuation in PEX and that PEX and TEX are separate diseases. PLOS
One, December 2020 33301460/
https://pubmed.ncbi.nlm.nih.gov/33301460/
April 2021
Academy Express ฉบับวันที่ 24
April 2021
Extended ILM peeling
yields higher closure rate for full thickness macular hole
Researchers compared 1- and 2-disc diameter conventional internal limiting
membrane (ILM) peeling for large full thickness macular holes. The extended
procedure led to a higher closure rate, particularly among patients with
chronic full thickness macular holes for more than 6 months. However, visual
outcomes were comparable in both groups. Eye, November 2020
https://pubmed.ncbi.nlm.nih.gov/33159177/
Academy Express ฉบับวันที่ 17
April 2021
IOP readings of
edematous eyes appear to be lower with GAT than other tonometers
Researchers assessed IOP of 60 patients with corneal edema after
phacoemulsification using 4 different tonometers. Pressure reading with
Goldmann applanation tonometry (GAT) tended to be lower than those obtained by
the other tonometers, particularly the Tono-Pen. Caution should be used when
interpreting GAT IOP readings of edematous corneas, the authors conclude. Journal
of Glaucoma, October 2020
https://pubmed.ncbi.nlm.nih.gov/33137014/
Academy Express ฉบับวันที่ 10
April 2021
Early surgery and
amblyopia treatment should be considered for childhood glaucoma
This retrospective study identified prognostic factors for poor visual outcomes
in 45 glaucomatous eyes of children 4 years or younger. Approximately 64% of
eyes had poor visual acuity, often due to deprivation amblyopia. Prognostic
factors for poor vision included secondary glaucoma, a diagnosis at 3 months or
younger, and an interval of 3 months or longer before surgery. Journal of
Pediatric Ophthalmology & Strabismus, September 2020
https://pubmed.ncbi.nlm.nih.gov/32956477/
Academy Express ฉบับวันที่ 3
April 2021
Endogenous
endophthalmitis yields poor visual outcomes even after treatment
This retrospective study describes 29 eyes with endogenous endophthalmitis. The
most common causative organism was Streptococcus spp. Positive vitreous
cultures were significantly tied to unfavorable visual outcomes. Even with
early treatment, the rate of evisceration and enucleation remained high. Journal
of Ophthalmology, December 2020
https://pubmed.ncbi.nlm.nih.gov/33489338/
March 2021
Academy Express ฉบับวันที่ 27
March 2021
Retained IOFB linked
to poor outcomes in post-traumatic endophthalmitis
Researchers report prognostic factors for poor visual outcomes in 66 patients
with post-traumatic endophthalmitis after open globe injury. Analysis revealed
that a retained intraocular foreign body was significantly linked to poor
visual outcomes. Most cases were caused by gram-positive organisms,
particularly Bacillus cereus. International Journal of Ophthalmology,
December 2020
https://pubmed.ncbi.nlm.nih.gov/33344198/
Academy Express ฉบับวันที่ 20
March 2021
Baseline vision, steroid
treatment affected visual outcomes in NMOSD-ON
This retrospective study identified prognostic factors for visual outcomes
after the first episode of neuroretinitis optica spectrum disorder-related
optic neuritis (NMOSD-ON). Assessment of 63 eyes revealed that a baseline BCVA
of counting fingers or better and intravenous methylprednisolone treatment
within 21 days of symptom onset were factors for good visual outcomes. Clinical
Ophthalmology, December 2020
https://pubmed.ncbi.nlm.nih.gov/33304093/
Academy Express ฉบับวันที่ 13
March 2021
Recurrent
Vogt-Koyanagi-Harada disease linked to altered choroidal volume
The authors examined 3D choroidal volume changes in patients with recurrent
Vogt-Konayagi-Harada disease. Using enhanced depth imaging OCT, they found
alterations choroidal volume during the recurrent stage of disease, even in an
absence of anterior segment inflammation. The findings suggest central
choroidal volume may serve as a biomarker for detecting choroidal morphological
change in this patient population. Current Eye Research, November 2020
https://pubmed.ncbi.nlm.nih.gov/33215546/
Academy Express ฉบับวันที่ 6
March 2021
Patients with MOG-IgG
optic neuritis tend to have better visual outcomes
A new study describes the clinical characteristics and long-term visual
outcomes of optic neuritis in Thailand. Researchers assessed 28 eyes with
MOG-IgG optic neuritis and 59 with AQP4-IgG optic neuritis during an 11-year
period. Patients with MOG-IgG disease tend to present with bilaterality and
optic disc edema and have better visual outcomes compared with patients with
AQP4-IgG disease. Clinical Ophthalmology, November 2020
https://pubmed.ncbi.nlm.nih.gov/33273804/
February 2021
Academy Express ฉบับวันที่ 27
February 2021
Genetic polymorphisms
tied to severe ocular complications in acetaminophen-related SJS/TEN
The authors investigated the role of genetic polymorphism in 20 Thai patients
with acetaminophen-related Steven-Johnson (SJS)/ toxic epidermal necrolysis
(TEN). Within the cohort, severe ocular complications was strongly associated
with human leucocyte antigen (HLA)-B*44:03 and moderately association with
HLA-A*33:03 and HLA-C*07:01. British Journal of Ophthalmology,
https://pubmed.ncbi.nlm.nih.gov/33229345/
Academy Express ฉบับวันที่ 20
February 2021
Vitrectomy provides
favorable anatomical success in AIDS patients with retinal detachment
This analysis evaluates outcomes in 45 patients (52 eyes) with AIDS undergoing
vitrectomy for cytomegalovirus retinitis-related retinal detachment. Over a
mean follow-up of 42 months, primary anatomical success was achieved in 86% of
eyes and 65% had a VA of 20/200 or better. The use of highly active
antiretroviral therapy prior to surgery and early vitrectomy increased the
probability of achieving both anatomical and VA success. Medicine
(Baltimore), October 2020
https://pubmed.ncbi.nlm.nih.gov/33120835/
Academy Express ฉบับวันที่ 13
February 2021
PFCL use can yield
satisfactory retinal reattachment
A new study describes the outcomes of retinal detachment repair by vitrectomy
and perfluorocarbon liquid (PFCL) tamponade. Among 122 study eyes, short- to
medium-term PFCL tamponade achieved a high satisfaction rate. Post-operative
hypotony was a predictor for unfavorable visual and anatomical outcomes. BMC
Ophthalmology, September 2020
https://pubmed.ncbi.nlm.nih.gov/32873279/
Academy Express ฉบับวันที่ 6
February 2021
Characterization of
HIV-associated optic neuritis
These findings suggest CD4 cell counts and viral load may help identify the
type of acute optic neuritis (ON) in patients infected with HIV. Among 10 study
patients, those with infectious ON had low initial CD4 counts and high viral
loads while patients with noninfectious ON had increasing CD4 cell counts and
undetectable HIV viral load after antiretroviral therapy. International
Medical Case Reports Journal, November 2020
https://pubmed.ncbi.nlm.nih.gov/33204180/
January 2021
Academy Express ฉบับวันที่ 30
January 2021
Some patients may benefit from using an eye drop guide for
self-administering medication
Researchers describe the usefulness of an eye drop guide device for
self-administering glaucoma medication. After 4 to 6 months, approximately 19%
of 57 patients used the guide everyday while 46% never used it. The findings suggest
an eye drop guide is most effective for patients using only 1 medication
administered in a standing or sitting position. Clinical Ophthalmology,
November 2020
https://pubmed.ncbi.nlm.nih.gov/33177804/
Academy Express ฉบับวันที่ 23
January 2021
Glycerin-preserved corneoscleral patch grafts effective for GDD implantation
This study investigates outcomes for glycerin-preserved human-donor
corneoscleral tissue as the patch graft for glaucoma drainage device (GDD)
implantation. Among 102 glaucoma patients, the 5-year survival rate of the
corneoscleral graft was 96%. The patch graft-related complications were
comparable to other materials Journal of Glaucoma, November 2020
https://pubmed.ncbi.nlm.nih.gov/32890110/
Academy Express ฉบับวันที่ 16
January 2021
CMET can lead to cornea-like epithelium in successful cases
A 13-patient study suggests successful autologous cultivated oral mucosal
epithelial transplantation (COMET) can lead to a predominant cornea-like
epithelium at long-term follow-up. Failed cases had a mainly conjunctival
phenotype. However, all eyes had evidence of oral mucosal epithelial cells. Cornea,
October 2020
https://pubmed.ncbi.nlm.nih.gov/33079916/
Academy Express ฉบับวันที่ 9
January 2021
Advanced stage presentation hinders effective management of
retinoblastoma
This retrospective study assessed whether new therapeutic approaches have
improved clinical outcomes in patients with retinoblastoma in Thailand. Medical
records of patients treated at a single hospital revealed that survival rates
and globe-saving rates appear to have improved but advanced stage presentation
remained the major obstacle. Pediatric International, October 2020
https://pubmed.ncbi.nlm.nih.gov/33022851/