เผยแพร่ผลงานวิจัยของจักษุแพทย์ไทย ในจดหมายข่าว Academy Express
Updated 2021-12-25 08:40:00
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อ่านผลงานวิจัยในจดหมายข่าว Academy Express-Asia Pacific Edition ฉบับย้อนหลัง
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Academy Express ฉบับวันที่ 18 Dec 2021
Yttrium
aluminium garnet lasers improved meibomian gland dysfunction in patients with
baggy eyelids
Investigators
studied the effectiveness and safety of upper and lower eyelid treatment with
combined application of three modes of 2940-nm erbium-doped yttrium aluminium
garnet (Er:YAG) and 1064-nm neodymium- doped yttrium aluminium garnet (Nd:YAG)
lasers in patients with baggy eyelids who exhibited meibomian gland dysfunction
(MGD). The primary endpoint was meibum quality score at 16- and 24-week follow-
ups; secondary endpoints were ocular surface index scores, tear film lipid
layer thicknesses, tear break up times (TBUTs), Oxford scheme grades, and
meibography grades at 16- and 24-week follow-ups. The results showed
significantly improved meibum quality in patients with MGD; it ameliorated
symptoms and signs of dry eye disease at 4 weeks after completion of laser
treatment.
Clinical Ophthalmology, July 2021
https://pubmed.ncbi.nlm.nih.gov/34295145/
Academy Express ฉบับวันที่ 11 Dec 2021
Steroid
therapy in combination with endoscopic optic nerve decompression for direct
traumatic optic neuropathy: a case-series
The authors
retrospectively reviewed the medical records of 13 patients (15 eyes) with
direct traumatic optic neuropathy to evaluate the outcomes of steroid therapy
in combination with endoscopic optic nerve decompression surgery. The main
outcome was visual acuity improvement after the treatment. Despite poor
prognosis of the disease, prompt treatment with this combined protocol provided
a favorable success rate, with most patients having stable vision and nearly
half having visual improvement by reducing intracanalicular pressure of the
optic nerve. Journal of the Medical Association of Thailand, July 2021
http://www.jmatonline.com/index.php/jmat/article/view/12657
Academy Express ฉบับวันที่ 4 Dec 2021
Visual
outcome of endogenous endophthalmitis tied to initial visual acuity
The
investigators evaluated 10-year visual outcomes of patients with endogenous
endophthalmitis (EE) in Thailand. Thirty-eight patients (40 eyes) were
diagnosed with EE at the mean age of 42. Among the identifiable pathogens
(71.1% culture positive), the causative agents were predominantly gram-negative
bacteria (48.1%). The most common species was Klebsiella pneumoniae (25.9%).
About a quarter of the patients required surgical eye removal, and of the
remaining 45.7% had visual acuity (VA) worse than hand motion at one month
after the infectious episode. Poor initial visual acuity is the only prognostic
factor of a poor early post-treatment visual outcome of EE. Scientific
Reports, July 2021
https://pubmed.ncbi.nlm.nih.gov/34253792/
November 2021
Academy Express ฉบับวันที่ 13 Nov 2021
Clinic-based
eye disease screening by non-expert personnel is useful for diagnosis
Investigators
looked to determine the accuracy of visual acuity, tonometry, and fundus
photography tests by non-ophthalmic personnel for age-related macular
degeneration (AMD), diabetic retinopathy (DR), glaucoma, and cataract, from
each of 3 enrolling clinics, Patients 250 years old were screened, and those
with positive screening test results in either eye and a 10% random sample with
negative results in both eyes were referred for an ophthalmology examination.
Fundus photography screening had the highest yield for DR (sensitivity: 67%);
visual acuity screening for cataract (sensitivity:89%), and intraocular
pressure screening for glaucoma or suspected glaucoma (sensitivity: 25%), The
burden of disease was relatively high, with at least 1 of the diseases of
Interest detected in 25% of participants from the diabetes clinic, 34% from the
thyroid clinic, and 21% from the general clinic. American Journal of
Ophthalmology, July 2021
https://pubmed.ncbi.nlm.nih.gov/33823160/
Academy Express ฉบับวันที่ 6 Nov 2021
Long-term
outcomes of Boston Type I keratoprosthesis
This study
reviewed the long-term outcomes,
anatomical retention, and complications
of Boston type I
keratoprosthesis (KPro) in retrospective, Interventional case studies, Over the mean
follow-up time of 83.4 ± 28.4 months, 56% of eyes
demonstrated improved best-corrected visual acuity. The anatomical retention rate was 89%, and the functional success rate was 44% (retained KPro with BCVA ≥ 3/60), Eyes with ocular surface disease (OSD) had significantly more
complications than those without OSD. The most common
complications were retroprostetic membrane formation (56%) and Infection (48%),
Infection Incidence
was
significantly lower in eyes using topical 0.1% amphotericin B and 5% povidone lodine.
Boston type I KPro could be an alternative treatment for patients with
conventional PKP failure, especially with appropriate patient selection and
complication prevention. Standard prophylactic antibiotics with the addition of
topical 0.1% amphotericin B and 5% povidone iodine might be optional effective
regimens for infection prevention, especially in tropical countries. American
Journal of Ophthalmology, June 2021
https://pubmed.ncbi.nlm.nih.gov/34102154/
October 2021
Academy Express ฉบับวันที่ 30 Oct 2021
Outcome
of simple limbal epithelial transplantation for limbal stem cell deficiency
verified
This study evaluated the efficacy and outcome of simple limbal epithelial transplantation (SLET) both autologous SLET (autoSLET) and living-related allogenic SLET (Lr-alloSLET) for limbal stem cell deficiency (LSCD) using epithelial phenotype detection (impression cytology with immunofluorescence staining: ICIF, in vivo confocal microscopy: IVCM, and immunohistochemistry analysis), integrated with clinical manifestation. The efficacy of SLET was excellent with an overall survival rate of 89.3% at 2 years and 75.6% at 3 years with no difference between autoSLET and Lr-alloSLET. Visual improvement was achieved in both SLET groups. Limbal explants can regenerate and restore the corneal surface while maintaining the characteristics of limbal stem cells as shown by epithelial phenotype detection and immunohistochemistry integrated with clinical evaluation. Ocular Surface, June 2021
https://pubmed.ncbi.nlm.nih.gov/34214675/
Academy Express ฉบับวันที่ 23 Oct 2021
Radiological
characteristics of extraocular muscles in patients with MG with ocular
manifestations
In this
case-control study, researchers used magnetic resonance imaging or computed
tomography scan to analyze radiological characteristics of the extraocular
muscles (EOMs) in patients with myasthenia gravis (MG) with ocular
manifestations, compared to a control group. Atrophic EOMs were frequently
found in the MG group, particularly in chronic cases. The results highlight the
importance of muscle involvement in MG and may be helpful for clinical
decision-making, Clinical Ophthalmology, June 2021
https://pubmed.ncbi.nlm.nih.gov/34103891/
Academy Express ฉบับวันที่ 16 Oct 2021
Comparison
of ocular complications and efficacy of PST vs. PTS botulinum toxin injection
in BEB
This
randomized controlled trial recruited 24 participants who visited a botulinum
toxin clinic. Each participant received preseptal (PST) BONT injection in one
eye and pretarsal (PTS) BoNT injection in the fellow eye to address benign
essential blepharospasm (BEB). Symptoms were recorded and measured 1 and 3
months after injection. All participants were examined by a single
investigator, who was masked to the injection allocation. There was a
statistically significant higher rate of self-reported lagophthalmos in PTS
(52.17%) than with PST (30.43%). Efficacy and other complication outcomes were
not statistically significant between the injection techniques. American
Journal of Ophthalmology, May 2021
https://pubmed.ncbi.nlm.nih.gov/33965414/
Academy Express ฉบับวันที่ 9 Oct 2021
The
ocular microbiome is compromised in Stevens-Johnson syndrome
The ocular
surface microbiome maintains ocular
surface homeostasis, and since it is continuously exposed to the external environment, its microbiome, tears, and local
Immunity are vital for maintaining normal
conditions and preventing pathogen colonization, which commonly leads to opportunistic infection. Several approaches
were applied to Identify the ocular microbiome,
including conventional culture techniques and molecular sequencing techniques: Using 16s rRNA sequencing,
alterations in the type, proportion, and composition
of bacterial communities were observed in SJS patients compared to the healthy group; and conventional culture
techniques indicated a higher number of positive
bacterial cultures in the SJS group, SJS causes structural changes in the
ocular
surface and significantly affects Its
microbiome. Treatment using prebiotics and probiotics to re-establish the normal ocular
ecosystem and bring back a healthy ocular surface
awaits confirmation. Frontiers in Medicine (Lausanne), May 2021
https://pubmed.ncbi.nlm.nih.gov/34026783/
Academy Express ฉบับวันที่ 2 Oct 2021
Meibomian glands dropout in patients with inactive
thyroid related orbitopathy
This crass-sectional study evaluated the structure and function of
meibomian glands in 106 eves of 53 patients with thyroid related orbitopathy
(TRO) compared with 106 eyes of 53 age- and sex-matched controls without TRO
and demonstrated the significantly higher meibomian gland dropout in patients
with inactive TRO. On the basis
of these findings, we suggest that ophthalmologists should examine meibomian
glands' structure, in addition to their function, for early detection,
management, and prevention of further meibomian gland destruction in patients
with inactive TRO. PLOS ONE, April 2021