คลังวารสาร

คลังวารสาร

แสดง 21 - 30 จาก 128 รายการ


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Acute Postoperative Endophthalmitis

Created 2011-02-23 09:49:50 by คุณ System Administrator 238 Views


Review Article


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Central Retinal Vein Occlusion (CRVO) in Andropausal Male Patient Treated with Oral Testosterone

Created 2011-02-23 09:46:29 by คุณ System Administrator 215 Views

Abstract Central retinal vein occlusion (CRVO) is a common retinal vascular disorder with potentially blinding complications.The authors reported a 51-year-old male who presented with blurred vision in right eye for 2 weeks. Visual acuity was 6/200 and fundus showed sign of central retinal vein occlusion. There were no explainable causes from patientûs history, physical examination and investigations except history of 6-year testosterone undecanoate 80 mg per day ingestion from andropausal clinic. The patient was treated with discontinuing testosterone, intravitreous bevacizumab 1.25 mg and 6-month warfarin ingestion. Visual acuity continuously improved, being 20/30 after 1 year. Oral testosterone supplement might be the most explainable cause of CRVO in this patient. However, co-incidence canût be excluded. Further study should be performed. Thai J Ophthalmol 2010; July-December 24(2): 127-132. Keywords: CRVO, androgen, testosterone, thrombosis, bevacizumab
Case Report


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Efficacy of Intravitreal Bevacizumab Injection for the Treatment of Proliferative Diabetic Retinopathy: A Pilot Study

Created 2011-02-23 09:45:44 by คุณ System Administrator 191 Views

Abstract Purpose: To evaluate the efficacy of intravitreal bevacizumab on persistent or new retinal neovascularizations (NV) in proliferative diabetic retinopathy (PDR) after full panretinal photocoagulation (PRP). Methods: This interventional case series included 8 eyes of 8 patients with PDR who had persistent or new retinal NV after full PRP. Patients underwent Snellen visual acuity testing, measurement of intraocular pressure, ophthalmoscopic examination and fundus photography at baseline and follow-up visits. After intravitreal injection of 1.25 mg/0.05 ml of bevaciumab, the first ophthalmoscopic examination was performed within 1 day and repeated at 1 week, 3 months and 6 months. Results: All 8 patients recruited to this study had type II diabetes for a mean period of 12.13 years. Only 4 patients had good glycemic control (HbA1C < 6.5). After a single dose of bevacizumab, complete resolution of retinal NV was found in 6 patients (75%) at 3 months. The reinjection was required in 2 patients at 2 and 3 months due to the occurring of new retinal NV. After 6 months follow-up period, all patients had complete resolution of retinal NV. Visual improvement was demonstrated in all patients after treatment. Adverse events were detected in 2 patients (25%). Two patients had minimal subconjunctival hemorrhage and one patient also had mild anterior uveitis. Conclusion: Intravitreal bevacizumab injection seemed to be a safe and effective adjunctive therapy to PRP in the treatment of PDR with recurrent or persistent retinal NV after full PRP. Large clinical trials are needed to evaluate alternative dosing (multiple and/or periodic injection) and further assess the efficacy and safety of intravitreal bevacizumab as an adjunctive therapy in management of PDR. Thai J Ophthalmol 2010; July- December 24(2): 120-126. Keywords: bevacizumab, Avastin, proliferative diabetic retinopathy, retinal neovascularization
Original Articles


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Detection of Glaucomatous Optic Neuropathy in Early Glaucoma Using Moorfields Regression Analysis (MRA) and Glaucoma Probability Score (GPS) in Confocal Laser Scanning Ophthalmoscopy

Created 2011-02-23 09:44:46 by คุณ System Administrator 236 Views

Abstract Objective: To estimate the ability of Moorfields Regression Analysis (MRA) and Glaucoma Probability Score (GPS) in confocal scanning laser ophthalmoscopy (Heidelberg Retina Tomography, HRT 3) for detecting early glaucoma in Songklanagarind Hospital Design: Retrospective study. Materials and Methods: Charts of early POAG patients were reviewed. All subjects underwent complete ophthalmologic examination. The standard achromatic perimetry (SITA 24-2 or 30-2) and HRT were examined within 6 months apart. Early POAG was defined as glaucomatous optic neuropathy and visual field defect by SAP with MD score between -0.01 to -7.00 Db. çOut side normal limité of MRA and GPS was considered abnormal for confocal scanning laser ophthalmoscopy examination. Results: Fifty (80 eyes) early glaucoma patients were eligible for the study (19 males, 31 females). Mean age was 59.3+15.0 years. Mean MD score was - 4.19+1.7Db. Forty-three of eighty eyes had abnormal MRA and 56 eyes had abnormal GPS. The sensitivity of GPS was 70.0% and for MRA was 53.7%. Conclusion: GPS showed greater sensitivity than MRA for detection of glaucomatous optic neuropathy in early POAG patients. This may due to variability of contour line placement for MRA. Thai J Ophthalmol 2010; July-December 24(2): 114-119. Keywords: Early primary open angle glaucoma, Confocal laser scanning ophthalmoscopy, Moorefields Regression Analysis (MRA), Glaucoma Probability score (GPS)
Original Articles


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Inpatient Eye Problems Requiring Ophthalmology Consultation in Chiang Mai University Hospital

Created 2011-02-23 09:44:03 by คุณ System Administrator 255 Views

Abstract Objective: To review ophthalmology consultation while patients were admitted with various conditions in aspects of general characteristics, the reasonability and the system of caring these patients. Design: A retrospective study. Methods: Reviewed inpatient medical records consulted to ophthalmology department from February 2009 through May 2009 Results: 303 patients were consulted to ophthalmology unit in 4 months of study. Most of them were from department of Internal Medicine, Pediatrics, and General surgery. The most common reason for consultation was helping in part of diagnosis 88 (29.2%), the second was screening for retinopathy including diabetic retinopathy, chloroquine maculopathy, cytomegalovirus retinopathy, retinopathy of prematurity 76 (27.1%) the third was new developing eye problems during hospitalization 44 (15.7%). The consultations were reasonable for inpatient consultation as emergency, urgency, ot necessary conditions 148 (52.9%) while the other 133 (47.5%) should be appointed for out-patient department instead. Conclusion: Ophthalmologic evaluation, diagnosis, and treatment are sometimes hard for non-ophthalmologists. However, understanding characteristics of eye problems required for urgency or non-urgency conditions is valued for determination to consult as inpatient setting that is more time-consuming or as out-patient. The data evaluated in this study is helpful for the general physicians, and the ophthalmology residents, leading to quality and cost-effectiveness of inpatient consultation system. Thai J Ophthalmol 2010; July-December 24(2): 101-113.
Original Articles


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การฉีดยา Bevacizumab เข้าในช่องหน้าตาในผู้ป่วยต้อหินชนิด Neovascular

Created 2011-02-23 09:42:59 by คุณ System Administrator 261 Views

Abstract Purpose: To determine the efficacy of intracameral bevacizumab injection in regression of iris neovascularization (NVI) and control of intraocular pressure (IOP) in neovascular glaucoma (NVG). Design: Prospective, consecutive study Methods: 20 eyes of 20 patients diagnosed with NVI and NVG were included. All patients had complete eye examination including IOP measurement and anterior segment photography. Bevacizumab (0.1 mg/0.04 ml) was injected intracamerally in each patient. Patients were examined at 1, 2, and 4 weeks post-injection. Each patient had a repeat injection at one week if NVI persisted in at least 2 quadrants. Results: NVI was regressed partially at one week and significantly at two weeks following intracameral bevacizumab injections. Mean IOP was significantly lowered at 1, 2, and 4 weeks post injection. No signs of corneal endothelial toxicity were observed on slit-lamp examination. IOP of 2 eyes with open angle was controlled with topical medication. Trabeculectomy with mitomycin C was necessary for the other 18 eyes. Conclusions: The intracameral bevacizumab injection was effective in regression of iris neovascularization. It may help in controlling IOP in eyes with open-angle NVG and impede progression of PAS in those eyes. Thai J Ophthalmol 2010; July-December 24(2): 95-100. Keywords: Neovascular glaucoma, Iris neovascularization, Bevacizumab
Original Articles


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การประเมินรูปแบบการใช้เลนส์สัมผัสหลายระยะที่มีจำหน่ายในประเทศไทย

Created 2011-02-23 09:40:31 by คุณ System Administrator 312 Views

Abstract Objective: A study was conducted to evaluate multifocal contact lens patterns available in Thailand in presbyopes. Materials and Methods: A prospective study was conducted on sixty healthy eye presbyopes who had astigmatism < 0.75 diopter, and who had given consent to participate in the trial. The subjects were evaluated on their distance and near vision, stereopsis, and for dominant and non-dominant eyes. Monthly replacement soft multifocal contact lenses (Frequency˙ 55 Multifocal) available in Thailand were introduced to the subjects; the distance lens (D lens) was applied to the dominant eye and the near lens (N lens) was applied to the non-dominant eye. The subjects were categorized into 3 groups (20 subjects each) based on distance vision: group 1 were myopic presbyopes and applied D lens + N lens, and D lens + D lens; group 2 were hyperopes and applied D lens + N lens, D lens + D lens, and N lens + N lens, and group 3 were emmetropes and applied D lens + N lens, N lens + N lens, and only N lens. They were assigned to use the lenses 1 to 2 weeks for each pattern. Their vision was compared among each pattern based on best corrected vision. Results: Group 1 revealed statistical significance only in the near vision (p<0.05), in which the pattern D lens + N lens was better than D lens + D lens. Group 2 showed data for both the distance and near visions were statistically significant (p<0.05), for the distance vision the N lens + N lens was the worst pattern, while the D lens + D lens was the worst pattern for the near vision. Group 3 indicated statistical significance only in the distance vision (p<0.05), for which using only N lens was the best pattern, while the N lens + N lens was the worst pattern. Stereopsis indicated no statistical significance for any pattern in all groups. However, stereopsis decreased from the best corrected vision by 59.38%. Discussion: Myopic and hyperopic presbyopes should apply the D lens + N lens, while emmetropic presbyopes should apply only N lens. Thai J Ophthalmol 2010; July-December 24(2): 86-94. Keywords: multifocal contact lens, presbyopia, dominant eye, non-dominant eye
Original Articles


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ผลของ Mitomicin C (MMC) ต่อเซลล์กระจกตาด้านในภายหลังการผ่าตัดต้อเนื้อ

Created 2011-02-23 09:38:09 by คุณ System Administrator 469 Views

Abstract Objective: To compare the change of corneal endothelium in patients undergoing pterygium excision with conjunctival autograft and with or without adjunctive mitomycin C (MMC). Design: Prospective randomized study. Methods: A prospective study in pterygium patients who were operated with or without MMC in Ramathibodi hospital during April 2009 - September 2009. Patientsû age, gender, corneal endothelial cell density, polymegethism, and pleomorphism at preoperative period, 1 month, and 3 months post operation were recorded. The results were analysed by paired t-test. Recurrence and complication were observed until January 2010. Recurrence was analysed by Fisherûs exact test. Results: There were 18 eyes of 18 patients included in this study, 9 eyes were operated with adjunctive MMC and 9 eyes without MMC. There were no statistical significance in corneal endothelial cell density (P = 0.366, 0.950, and 0.703 respectively), polymegethism (P = 0.587, 0.258, and 0.116 respectively) and pleomorphism (P = 0.566, 0.217, and 0.345 respectively) of preoperative period, 1 month and 3 months post operation in the two groups. Recurrences were found in 2 eyes (22.22%) of control group at the 3rd month (P=0.470, Fisherûs exact test). No serious complication was found in either group. Conclusions: Effects on corneal endothelium in pterygium excision and conjunctival autograft with or without MMC did not differ significantly. There was no statistical significance in recurrence rate between MMC and control groups. Thai J Ophthalmol 2010; July-December 24(2): 79-85. Keywords: Pterygium excision, Conjunctival autograft, Corneal endothelial cell density, Polymegethism, Pleomorphism, Mitomycin C.
Original Articles