เผยแพร่ผลงานวิจัยของจักษุแพทย์ไทย ในจดหมายข่าว Academy Express

Updated 2022-04-16 18:29:00






เผยแพร่ผลงานวิจัยของจักษุแพทย์ไทย ในจดหมายข่าว Academy Express




Academy Express เป็นจดหมายข่าว อิเล็กทรอนิกส์ ที่จัดทำโดย American Academy of Ophthalmology ส่งทาง email ทุกสัปดาห์ ถึงสมาชิกของ 19 องค์กร วิชาชีพทางจักษุวิทยาใน Asia Pacific region รวมทั้ง RCOPT ราชวิทยาลัยฯเชิญชวนสมาชิกจักษุแพทย์ ติดตาม ผลงานวิจัยของจักษุแพทย์ไทย ในคอลัมน์ ASIA PACIFIC JOURNAL STUDIES ในจดหมายข่าวดังกล่าว

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Academy Express Asia Pacific Edition ฉบับวันที่ 26 Mar 2022

 

Pythium keratitis is a significant problem for CL wearers in areas with water contamination

 

This case study discusses the predisposing factors, clinical presentations, and treatment outcomes of 6 patients who were treated at a single center in Thailand for contact lens (CL)-related keratitis due to Pythium insidiosum infection (Pythium keratitis). Five patients had used soft CLs, whereas 1 patient used a rigid gas permeable lens. All of the patients had a history of water contamination. The mean duration of Pythium keratitis from onset was 7.8 days, and the feature of tentacle-like lesions radiating in a reticular pattern was observed in all patients. Each patient received therapeutic – penetrating keratoplasty therapy because of topical and systemic medication failure, and one patient subsequently underwent enucleation. Cornea, November 2021

https://pubmed.ncbi.nlm.nih.gov/33470674/

 

 

Academy Express Asia Pacific Edition ฉบับวันที่ 19 Mar 2022

 

Neuroimaging can identify microvasculopathy in patients with fourth cranial nerve palsy

 

Investigators studied the etiologies of isolated fourth cranial nerve palsy diagnosed between January 2009 and July 2020 in 158 patients seen at a single center in Thailand. Nearly all of the patients had unilateral palsy. Fifty-eight percent of the unilateral cases were congenital in origin; other etiologies included microvasculopathy (28%) and intracranial neoplasm (8%). Of the 4 cases of bilateral palsy, 3 were caused by trauma with closed head injury and 1 was caused by ruptured arteriovenous malformation. Forty-nine percent of the patients with microvasculopathy-related fourth nerve palsy underwent neuroimaging, with normal findings, and all patients' symptoms resolved within 6 months of symptom onset. The authors recommend considering neuroimaging in patients who might be at risk for microvasculopathy. International Ophthalmology, October 2021

https://pubmed.ncbi.nlm.nih.gov/34014458/

 

 

Academy Express Asia Pacific Edition ฉบับวันที่ 12 Mar 2022

 

Excessive blinking in children is not associated with greater duration of visual display use

 

This cross-sectional case-control study enrolled 200 healthy children aged 6-14 years to evaluate the causes of excessive blinking and identify whether excessive blinking was linked to certain visual activities, primarily visual display terminal use. Participants were placed into either the group with chief complaints of excessive blinking (study group) or a control group. There was a significantly higher percentage of participants in the study group diagnosed with dry eyes (73% vs. 6%, respectively), allergic conjunctivitis (41% vs. 0%, respectively), and tic disorder (19% vs. 9%, respectively) compared with the control group. However, there was no significant difference in the duration of visual activities between groups. Journal of the Medical Association of Thailand, October 2021

http://www.jmatonline.com/index.php/jmat/article/view/13064

 

 

Academy Express Asia Pacific Edition ฉบับวันที่ 5 Mar 2022

 

Nearly 60% of grafts fail in the 10years after corneal transplantation

 

In this 15-year retrospective cohort study, investigators evaluated long-term graft survival outcomes and prognostic factors for graft failure in corneal transplantation. Seven hundred four surgeries were performed at a tertiary referral hospital in Thailand during this time period; overall graft survival rates at 1, 3, 5, and 10 years were 87.5%, 72.0%, 59.2%, and 41.7%, respectively. The median graft survival period was 81.7 months. Per multivariate analysis, the three main prognostic factors for graft failure were primary diagnosis, pre-existing glaucoma or raised intraocular pressure, and previous graft rejection. Clinical Ophthalmology, October 2021

https://pubmed.ncbi.nlm.nih.gov/34703206/

 

 

Academy Express Asia Pacific Edition ฉบับวันที่ 26 Feb 2022

 

Over 8% of Thai university students suffer from dry eye disease, according to recent study data

 

Investigators explored the prevalence of dry eye disease (DED) and its associated risk factors among 4,111 university students in Bangkok, Thailand. The mean age was 18.8 years; 70% of participants were female, 21% had a history of contact lens use, and 51% reported high screen time (>8 hours/day). The estimated prevalence of DED was 8.2%. Contact lens use, high screen time, and male gender were significantly associated with a greater risk of DED (odds ratios 2.49, 1.43, and 1.39, respectively). These findings can raise awareness of the presence of DED in young adults and provide important information for public health initiatives for university students. PLoS One, October 2021

https://pubmed.ncbi.nlm.nih.gov/34597336/

 

 

Academy Express Asia Pacific Edition ฉบับวันที่ 5 Feb 2022

 

Predicting poor visual outcomes for patients with Behcet disease with FA and BOS24

 

This retrospective study evaluated the application of the Behcet disease ocular attack score 24 (BOS24) scoring system and fluorescein angiographic (FA) findings in predicting poor visual outcome in 38 patients (73 eyes) with ocular Behcet disease. The most common FA findings were optic disc hyperfluorescence, diffuse posterior pole leakage, and diffuse peripheral leakage. There was a significant association between poor visual outcome and BOS24 scores of 26, arterial narrowing, and severe posterior pole leakage. Combining significant FA findings with BOS24 scores 26 results in an increased relative risk of

developing poor visual acuity. The authors conclude that FA is an important investigation tool for predicting poor visual outcome, but BOS24 scores may be a useful alternative when FA is unavailable. International Journal of Retina and Vitreous, August 2021

https://pubmed.ncbi.nlm.nih.gov/34454608/

 

 

Academy Express Asia Pacific Edition ฉบับวันที่ 29 Jan 2022

 

Post-traumatic endophthalmitis leads to poor subsequent visual outcome

 
The authors reviewed medical records of 591 patients with open globe injury and divided the patients into 2 groups: those with accompanied endophthalmitis and those with no endophthalmitis. The epidemiology, clinical characteristics, risk factors, and visual outcomes of post-traumatic endophthalmitis were studied. Higher proportions of intraocular foreign body (IOFB) and injuries related to high-velocity objects were noted in patients with endophthalmitis compared with those without endophthalmitis. Anterior wound location, presence of IOFB, and delayed presentation of >24 hours were significant risk factors for associated endophthalmitis. Final visual acuity (VA) of the overall population improved significantly; however, patients in the endophthalmitis group achieved a worse final VA than patients in the non-endophthalmitis group. Journal of Ophthalmic Inflammation and Infection, August 2021

https://pubmed.ncbi.nlm.nih.gov/34337691/

 

Academy Express Asia Pacific Edition ฉบับวันที่ 22 Jan 2022

 

Most normative corneal subbasal nerve characteristics do not differ with age

 

In this study, investigators examined normative characteristics of corneal subbasal nerves in different age groups (N 80 healthy participants aged 20-60 years) via laser scanning in vivo confocal microscopy (IVCM). Corneal IVCM was performed at the central cornea to analyze

the subbasal nerve plexus, the corneal nerve characteristics were then analyzed, and the corneal nerve tortuosity was graded. The results found that the corneal subbasal nerve numbers and densities were not significantly different among the age groups studied. However, there was an increase in tortuosity of the corneal nerve seen in people aged >40 years. Clinical Ophthalmology, August 2021

https://pubmed.ncbi.nlm.nih.gov/34465977/

 

 

Academy Express Asia Pacific Edition ฉบับวันที่ 15 Jan 2022

 

New diagnostic tools and treatments for retinal vasculitis are now available

 

Retinal vasculitis is inflammation of retinal blood vessels typically resulting from either infection or immune-mediated inflammatory processes. It may present as isolated ocular inflammation or as a component of severe or potentially fatal systemic disease. Ocular complications of retinal vasculitis include cystoid macular edema, neovascularization, tractional retinal detachment, and vitreous hemorrhage, which all greatly threaten vision. Multimodal imaging and thorough systemic investigations are the main tools for making a precise diagnosis, which can then be used to predict disease prognosis and visual outcome in order to preserve a patient's vision and possibly their life. This review aims to discuss the current understanding of retinal vasculitis as well as current diagnostic tools and treatments. Siriraj Medical Journal, August 2021

https://doi.org/10.33192/Smj.2021.64

 

 

Academy Express Asia Pacific Edition ฉบับวันที่ 8 Jan 2022

 

Association between antibody profiles and clinical outcomes can be used to adjust treatment for AIR

 

This retrospective cohort study evaluated antiretinal autoantibody profiles and their association with clinical outcomes of 44 patients in Thailand with AIR. Common clinical presentations were nyctalopia, blurred vision, constricted visual field, and nonrecordable electroretinography. Underlying malignancy and autoimmune diseases were found in 2 and 12 female patients, respectively. The study reported findings of 41 autoantibodies, with anti-a-enolase showing the highest prevalence, followed by anti-carbonic anhydrase II (CAII), anti-aldolase, and anti-glyceraldehyde-3-phosphate dehydrogenase (GAPDH). Anti-CAII autoantibodies showed significant association with age of onset, while anti-a-enolase and anti-GAPDH autoantibodies were significantly associated with nonrecordable electroretinography. Association between the antibody profiles and clinical outcomes may be used to direct and adjust AIR treatment plans and provide insights into its pathogenesis. Scientific Reports, July 2021

https://pubmed.ncbi.nlm.nih.gov/34294798/