เผยแพร่ผลงานวิจัยของจักษุแพทย์ไทย ในจดหมายข่าว Academy Express
Updated 2022-04-16 18:29:00
เผยแพร่ผลงานวิจัยของจักษุแพทย์ไทย ในจดหมายข่าว Academy Express
ท่านสมาชิกจักษุแพทย์ที่มีผลงานวิจัยใหม่ในวารสารวิชาการทางจักษุวิทยาที่เป็น indexed journal ส่งผลงานเพื่อเผยแพร่ใน Academy Express ฉบับต่อไปได้ที่ yyosanan@gmail.com หรือ admin@rcopt.org
Academy
Express Asia Pacific Edition ฉบับวันที่ 26
Mar 2022
Pythium keratitis is a significant problem for CL wearers
in areas with water contamination
This case study discusses the
predisposing factors, clinical presentations, and treatment outcomes of 6
patients who were treated at a single center in Thailand for contact lens
(CL)-related keratitis due to Pythium insidiosum infection (Pythium keratitis).
Five patients had used soft CLs, whereas 1 patient used a rigid gas permeable
lens. All of the patients had a history of water contamination. The mean
duration of Pythium keratitis from onset was 7.8 days, and the feature of
tentacle-like lesions radiating in a reticular pattern was observed in all
patients. Each patient received therapeutic – penetrating keratoplasty therapy
because of topical and systemic medication failure, and one patient
subsequently underwent enucleation. Cornea, November 2021
https://pubmed.ncbi.nlm.nih.gov/33470674/
Academy
Express Asia Pacific Edition ฉบับวันที่ 19
Mar 2022
Neuroimaging can identify microvasculopathy in patients
with fourth cranial nerve palsy
Investigators studied the etiologies
of isolated fourth cranial nerve palsy diagnosed between January 2009 and July
2020 in 158 patients seen at a single center in Thailand. Nearly all of the
patients had unilateral palsy. Fifty-eight percent of the unilateral cases were
congenital in origin; other etiologies included microvasculopathy (28%) and
intracranial neoplasm (8%). Of the 4 cases of bilateral palsy, 3 were caused by
trauma with closed head injury and 1 was caused by ruptured arteriovenous
malformation. Forty-nine percent of the patients with microvasculopathy-related
fourth nerve palsy underwent neuroimaging, with normal findings, and all
patients' symptoms resolved within 6 months of symptom onset. The authors
recommend considering neuroimaging in patients who might be at risk for
microvasculopathy. International Ophthalmology, October 2021
https://pubmed.ncbi.nlm.nih.gov/34014458/
Academy
Express Asia Pacific Edition ฉบับวันที่ 12
Mar 2022
Excessive blinking in children is not associated with
greater duration of visual display use
This cross-sectional case-control
study enrolled 200 healthy children aged 6-14 years to evaluate the causes of
excessive blinking and identify whether excessive blinking was linked to
certain visual activities, primarily visual display terminal use. Participants
were placed into either the group with chief complaints of excessive blinking
(study group) or a control group. There was a significantly higher percentage
of participants in the study group diagnosed with dry eyes (73% vs. 6%,
respectively), allergic conjunctivitis (41% vs. 0%, respectively), and tic
disorder (19% vs. 9%, respectively) compared with the control group. However,
there was no significant difference in the duration of visual activities
between groups. Journal of the Medical Association of Thailand, October 2021
http://www.jmatonline.com/index.php/jmat/article/view/13064
Academy
Express Asia Pacific Edition ฉบับวันที่ 5
Mar 2022
Nearly 60% of grafts fail in the 10years after corneal
transplantation
In this 15-year retrospective cohort
study, investigators evaluated long-term graft survival outcomes and prognostic
factors for graft failure in corneal transplantation. Seven hundred four
surgeries were performed at a tertiary referral hospital in Thailand during
this time period; overall graft survival rates at 1, 3, 5, and 10 years were
87.5%, 72.0%, 59.2%, and 41.7%, respectively. The median graft survival period
was 81.7 months. Per multivariate analysis, the three main prognostic factors
for graft failure were primary diagnosis, pre-existing glaucoma or raised
intraocular pressure, and previous graft rejection. Clinical Ophthalmology,
October 2021
https://pubmed.ncbi.nlm.nih.gov/34703206/
Academy
Express Asia Pacific Edition ฉบับวันที่ 26
Feb 2022
Over 8% of Thai university students suffer from dry eye
disease, according to recent study data
Investigators explored the prevalence
of dry eye disease (DED) and its associated risk factors among 4,111 university
students in Bangkok, Thailand. The mean age was 18.8 years; 70% of participants
were female, 21% had a history of contact lens use, and 51% reported high
screen time (>8 hours/day). The estimated prevalence of DED was 8.2%.
Contact lens use, high screen time, and male gender were significantly
associated with a greater risk of DED (odds ratios 2.49, 1.43, and 1.39,
respectively). These findings can raise awareness of the presence of DED in
young adults and provide important information for public health initiatives
for university students. PLoS One, October 2021
https://pubmed.ncbi.nlm.nih.gov/34597336/
Academy
Express Asia Pacific Edition ฉบับวันที่ 5
Feb 2022
Predicting poor visual
outcomes for patients with Behcet disease with FA and BOS24
This retrospective study evaluated the
application of the Behcet disease ocular attack score 24 (BOS24) scoring system
and fluorescein angiographic (FA) findings in predicting poor visual outcome in
38 patients (73 eyes) with ocular Behcet disease. The most common FA findings
were optic disc hyperfluorescence, diffuse posterior pole leakage, and diffuse
peripheral leakage. There was a significant association between poor visual
outcome and BOS24 scores of 26, arterial narrowing, and severe posterior pole
leakage. Combining significant FA findings with BOS24 scores 26 results in an
increased relative risk of
developing poor visual acuity. The
authors conclude that FA is an important investigation tool for predicting poor
visual outcome, but BOS24 scores may be a useful alternative when FA is
unavailable. International Journal of Retina and Vitreous, August 2021
https://pubmed.ncbi.nlm.nih.gov/34454608/
Academy
Express Asia Pacific Edition ฉบับวันที่ 29
Jan 2022
Post-traumatic
endophthalmitis leads to poor subsequent visual outcome
The authors reviewed medical records of 591 patients with open globe injury and
divided the patients into 2 groups: those with accompanied endophthalmitis and
those with no endophthalmitis. The epidemiology, clinical characteristics, risk
factors, and visual outcomes of post-traumatic endophthalmitis were studied.
Higher proportions of intraocular foreign body (IOFB) and injuries related to
high-velocity objects were noted in patients with endophthalmitis compared with
those without endophthalmitis. Anterior wound location, presence of IOFB, and
delayed presentation of >24 hours were significant risk factors for
associated endophthalmitis. Final visual acuity (VA) of the overall population
improved significantly; however, patients in the endophthalmitis group achieved
a worse final VA than patients in the non-endophthalmitis group. Journal of Ophthalmic Inflammation and Infection,
August 2021
https://pubmed.ncbi.nlm.nih.gov/34337691/
Academy
Express Asia Pacific Edition ฉบับวันที่ 22
Jan 2022
Most normative corneal
subbasal nerve characteristics do not differ with age
In this study, investigators examined
normative characteristics of corneal subbasal nerves in different age groups (N
80 healthy participants aged 20-60 years) via laser scanning in vivo confocal
microscopy (IVCM). Corneal IVCM was performed at the central cornea to analyze
the subbasal nerve plexus, the corneal
nerve characteristics were then analyzed, and the corneal nerve tortuosity was
graded. The results found that the corneal subbasal nerve numbers and densities
were not significantly different among the age groups studied. However, there
was an increase in tortuosity of the corneal nerve seen in people aged >40
years. Clinical Ophthalmology, August 2021
https://pubmed.ncbi.nlm.nih.gov/34465977/
Academy
Express Asia Pacific Edition ฉบับวันที่ 15
Jan 2022
New diagnostic tools and treatments for retinal vasculitis are
now available
Retinal
vasculitis is inflammation of retinal blood vessels typically resulting from
either infection or immune-mediated inflammatory processes. It may present as
isolated ocular inflammation or as a component of severe or potentially fatal
systemic disease. Ocular complications of retinal vasculitis include cystoid
macular edema, neovascularization, tractional retinal detachment, and vitreous
hemorrhage, which all greatly threaten vision. Multimodal imaging and thorough
systemic investigations are the main tools for making a precise diagnosis,
which can then be used to predict disease prognosis and visual outcome in order
to preserve a patient's vision and possibly their life. This review aims to
discuss the current understanding of retinal vasculitis as well as current
diagnostic tools and treatments. Siriraj Medical Journal, August 2021
https://doi.org/10.33192/Smj.2021.64
Academy
Express Asia Pacific Edition ฉบับวันที่ 8
Jan 2022
Association between
antibody profiles and clinical outcomes can be used to adjust treatment for AIR
This retrospective cohort study
evaluated antiretinal autoantibody profiles and their association with clinical
outcomes of 44 patients in Thailand with AIR. Common clinical presentations
were nyctalopia, blurred vision, constricted visual field, and nonrecordable
electroretinography. Underlying malignancy and autoimmune diseases were found
in 2 and 12 female patients, respectively. The study reported findings of 41
autoantibodies, with anti-a-enolase showing the highest prevalence, followed by
anti-carbonic anhydrase II (CAII), anti-aldolase, and
anti-glyceraldehyde-3-phosphate dehydrogenase (GAPDH). Anti-CAII autoantibodies
showed significant association with age of onset, while anti-a-enolase and
anti-GAPDH autoantibodies were significantly associated with nonrecordable
electroretinography. Association between the antibody profiles and clinical
outcomes may be used to direct and adjust AIR treatment plans and provide
insights into its pathogenesis. Scientific Reports, July 2021
https://pubmed.ncbi.nlm.nih.gov/34294798/