ABSTRACT The double-masked clinical study was conduct~d
in dry eye patients to compare the efficacy between Dakrina applied to one eye of a
patient randomly assigned and Tears Naturale applied to the contralateral eye of the same
patient. Ten patients were included in the study. The dry-eye state was evaluated by
observing the subjective symptoms and by determining clinical signs such as tear film
break-up time, degree of vital staining by Lissamine green, Schirmer's test with
anesthesia and the degree of conjunctival injection. In general, Dakrina showed a superior
effect. Due to the small number of subjects however, the difference found between the two
eye drops was not statistically significant at the p = 0.05 level.
Key words : break-up
time, dry eyes, Schirmer's test, topical treatment, vital staining