Retinoblastoma
in Two Decades of Ramathibodi
Skowrat
Kunavisarut M.D*
Somporn Suwimolsatian M.D*
Laksana
Pochanugool M.D**
Pongjan Hathirat M.D***
*Department of Ophthalmology,
** Department of Radiology,
*** Department of Pediatrics, Ramathibodi Hospital, Mahidol University
ABSTRACT We reviewed the records of retinoblastoma
patients in the Department of Ophthal mology, Ramathibodi Hospital during
1970 to 1992. There were 193 cases (106 males and 87 females), 58 cases
(30%) were bilateral. The mean age at diagnosis in bilateral cases was 27.48
+ - 16.37 months. The mean age at diagnosis of the unilateral cases was
34.89 + - 23.82 months. In unilateral cases, the frequency of right or left
eye involvement was not significantly different. 30.5% of cases were from north-eastern Thailand. Positive family history was
founnd in 3.6%. The most common presentation was leucocoria (51.79%).
Malignant cells in CSF
were found in 20.7% of bilateral cases, and 16.20% of unilateral cases.
Bone marrow study was positive in 31.91% and 28.3% respectively. Most patients
were treated by enucleation followed by radiation and chemotherapy. Some
cases received cryotherapy or photocoagulation in the second eyes. Second
malignancy, osteosarcoma developed in 3 cases. There was one case which
the tumor showed spontaneous regression.
Of the 135 unilateral
cases, 17.04% died within five years and 28.5% survived longer than five
years. Of the bilateral cases, 6.7% died within five years, and 24.14% survived
longer than five years. The rest were cases whose follow up period less
than five years and some who lost follow up.
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