ABSTRACT We
reported here three cases of osteogenic sarcoma after the treatment for retinoblas
toma.
The first case was a girl
with unilateral retinoblastoma and had been treated with enucleation and combined
chemotherapy and external irradiation since she was 1 8/12 year old. The osteosar
coma of right maxillary bone developed 8 1/2 years later. The second case
was a girl with bilateral retinoblastoma and was treated with enucleation
of her right eye and photocoagulation of her left eye since she was ten months
old. Her mother refused to have any further therapy neither chemo therapy
nor radiotherapy. The osteosarcoma of left lower limb was diagnosed by X-ray
7 years later. The last case was a boy with bilateral retinoblastoma whose
both eyes were enucleated and had been treated with both chemotherapy and
radiotherapy since he was 1 9/12 year old and osteos arcoma of left mandible
occurred 3 years later.
In this series the osteosarcoma
developed in both unilateral and bilateral retinoblastoma, and also in whom
with or without radiotherapy. Longterm follow up is imperative in retinoblastoma
survivors in order to detect late-development second malig nancies.